With the founding of Pennsylvania Hospital, Philadelphia became a center for medical science and physicians. People, particularly wealthy people, came from around the colonies to be treated and physicians became both renowned and wealthy themselves. The Shippen-Wistar house can lay claim to two medical connections.
The house was built for Dr. William Shippen a leading physician and educator who headed the medical department of the Continental Army from 1777-1781. It was then owned by Caspar Wistar, also a physician and educator in chemistry and anatomy at the University of Pennsylvania who lived in it from 1798 -1809.